96 to 384 – Challenges and Solutions

Seth P. Cohen Ph.D.

Associate Director, HTS

Millennium Pharmaceuticals, Inc.

The many advantages of transitioning high throughput screening assays from
96-well to 384-well will be outlined. Some of the challenges to developing and
implementing cell-based and biochemical assays for this higher density format include
changes in assay parameters, liquid handling, signal detection and data management.
Solutions to many of these challenges have been implemented at Millennium’s HTS facility
and will be discussed.

LRIG New England March 99 Meeting


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