index

Validation of Engineered Cell-Based Screens for G Protein-Coupled
Receptors

12/98

Presentation:  Validation of
Engineered Cell-Based Screens for G Protein-Coupled Receptors


E. William Radany, Ph.D.

Business Manager

Stratagene

G protein-coupled receptors and receptor tyrosine kinases are important targets for
drug discovery. High throughput screening (HTS) assays based on ligand binding to these
targets may yield biased results depending on the cellular environment in which the cloned
receptor resides. The use of engineered cell lines of defined signalling properties with
specific receptors provides new tools for HTS assays and the the study of orphan
receptors. This presentation will focus on the development of discovery platforms based on
reporter gene technology utilizing cells with specific signalling pathways.

Click here to start

Back to the
Meeting Presentations page


Back to The Laboratory Robotics
Interest Group homepage at

Scroll to top