Our client whose founders' come from both well known Pharmaceutical companies and some of the world most prestigious universities are developing and integrating unique approaches and capabilities in synthetic chemistry, chemical genetics, informatics, and biological screening. They are seeking a Head ofADME Tox . They currently have $70 million dollars in funding and they feel this position is critical for their success. This position is located in the Boston area.
This person will be the driving force behind leveraging cutting edge technology for providing PK and Tox data in a high-throughput format to increase the effectiveness and productivity to drug discovery. He or she will provide strong, hands-on leadership to the group, developing strategic direction, setting specific measurable milestones and monitoring progress against these goals.The candidate will play a key role in establishing a newly created department as well as providing critical scientific support of appropriate pre-clinical and clinical ADME data for discovery and clinical development groups downstream. This position will also be responsible for the evaluation, recommendation, and implementation of new in vitro models and cutting edge technology for providing PK and Tox data in a medium-to-high throughput screening format.
They are seeking someone with a Ph.D. in Pharmacokinetics, Drug Metabolism, Biochemistry or related discipline plus a minimum of 6 years experience (or M.S. plus 8 years) in the pharmaceutical industry. This person must have demonstrated accomplishments in the design and implementation of in vitro metabolism/inhibition assays, in vitro permeation assays, blood-brain barrier models, etc. are required. As well as experience in developing and validating bio-analytical assays for the detection of drug metabolites in biological matrices is desired of the candidate. The successful candidate will also have significant expertise in techniques (enzyme kinetics, cell-based assays, HPLC, LC/MS) and regulatory issues (GLP, ICH guidelines) necessary to support these evaluations. The qualified candidate will have a record of successful use of computational and in vitro PK and Tox models (metabolic stability/induction/inhibition, CYP pathways, permeation models, cytotoxicity models) in support of discovery programs. Excellent computer skills and supervisory experience are a must.
For further information about our R&D; related searches please contact:
Denise Milano Sprung
V.P. Search Services
[email protected]
Joseph Associates Inc.
631-351-5805 ext. 5
***We understand that this is a very small community, all paperwork and correspondences will be kept strictly confidential. CV's are only sent to clients with when candidates approve the submission.
Head of ADME Tox
Posted - 01/29/2003 : 15:29:48
