The Living Chip: A massively parallel microfluidics platform for
ultra-high throughput screening and compound library storageWe have developed a novel microarray technology for performing very large
numbers (potentially up to one million) of biochemical, chemical and
cell-based nanoliter volume screening and synthesis operations in a
massively parallel manner. The Living Chip is an array of precisely
machined through-holes retaining nanoliters of fluid by capillary action.
Sample loading, washing and recovery are operations that can be performed
manually or with simple automation. Mixing between co-registered
through-holes is achieved by stacking two or more precision aligned arrays
and optical assay read-outs are in parallel with a CCD imaging system. An
automated picker system transfers hits into lower density microtiter plates
for further analysis. We will present results demonstrating massively
parallel implementation of both homogeneous and inhomogeneous fluidic and
cell-based assay systems and applications of the chip for drug compound
library storage and management.
contact: "Robert Hess" <[email protected]>
The Living Chip
Posted - 04/19/2002 : 4:19:35 PM
