Vertex Pharmaceuticals Incorporated is leading the way in small molecule drug discovery. By pioneering new, innovative, faster approaches to drug discovery with a focus on chemogenomics, our goal is to set the standard for pharmaceutical research and development in the 21st century.

This individual performs high throughput analysis of crude bio-samples, mostly from drug metabolism studies, across multiple drug discovery projects; and works closely with drug metabolism group to evaluate new chemical entities, from lead optimization to selection of candidates, for development as therapeutic agents. Specific responsibilities include employing LC/MS/MS or LC/MS methods for quantitative analysis of xenobiotics and metabolites; developing and improving bioanalytical methods to maximize instrument use and streamline results reporting, and maintaining detailed documentation. May also be involved in conducting analyses on samples generated from pharmacokinetic and toxicological studies as needed.

Requires a BS/MS in Analytical Chemistry, Chemistry, Biochemistry, related field or equivalent combination of education and experience; hands-on experience with HPLC, LC/MS/MS method development, sample preparation and analysis. Experience with LC/MS control and quantification computer software, mass spectrometers, AB/Sciex, Thermo Finnigan or Micromass systems is essential. Good communication skills and the ability to learn new technologies as part of a multi-disciplinary team are a must.
We provide a highly stimulating working environment coupled with a high level of professional and intellectual challenge. In addition to competitive salary and benefits, we also offer equity participation and participation in a stock purchase program.

Apply online at www.vrtx.com

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