Assay miniaturization has pushed the limits of fluid handling. 384 and 1536 well screening requires accurate and reliable compound dispensing during the reformatting procedure. This time-consuming and wasteful step is eliminated with the SmartPlate?shipping, storing, and dispensing technology that includes integral dilution. A new concept assigns a DMSO dissolved compound to an individually addressable sealed tap. The taps are the storage, metering, dispensing, and diluting elements and formatted in a 384-well plate-based array. Compound dispense volumes range from 5-200nl. Reformatting, disposable tips, and wash cycles are eliminated. This presentation will highlight how SmartPlate10 works, implementation examples, and current performance data.