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<div id=cover-sheet>Please join us for the third seminar in the Pfizer Series

organized by BEACON on June 18 discussing DNA-guided medicine. This event is

co-presented by the Pioneer Valley Life Sciences Institute in Springfield, MA.


Full details are attached. We hope you can attend. Please share, post or

blast this information to your colleagues! It is open to the public free of

charge. RSVP requested.



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<div class=Section1>



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<p class=MsoNormal><font size=3 face="Times New Roman"><span style=’font-size:

12.0pt’><o:p> </o:p></span></font></p>



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<p class=MsoNormal align=center style=’text-align:center;border:none;

padding:0in;padding-bottom:0in;border-bottom:2.25pt solid #0099CC’><b><i><font

size=5 color="#003399" face="Times New Roman"><span style=’font-size:16.0pt;

color:#003399;font-weight:bold;font-style:italic’>Organized and presented by: <o:p></o:p></span></font></i></b></p>



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padding:0in;padding-top:0in’><b><i><font size=5 color="#003399"

face="Times New Roman"><span style=’font-size:16.0pt;color:#003399;font-weight:

bold;font-style:italic’><img width=99 height=53 id="_x0000_i1026"

src="cid:image002.jpg@01C9D95B.1F81C760">        </span></font></i></b><img

width=287 height=58 id="_x0000_i1027" src="cid:image003.gif@01C9D95B.1F81C760"><b><i><font

size=5 color="#003399"><span style=’font-size:16.0pt;color:#003399;font-weight:

bold;font-style:italic’><o:p></o:p></span></font></i></b></p>



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face="Times New Roman"><span style=’font-size:12.0pt’><o:p> </o:p></span></font></p>



<p class=MsoNormal style=’margin-left:1.5in’><font size=3 face="Times New
Roman"><span

style=’font-size:12.0pt’>                                                <img

width=84 height=126 id="_x0000_i1028" src="cid:image004.jpg@01C9D95B.1F81C760"></span></font></p>



<p class=MsoNormal><b><i><font size=2 face=Arial><span style=’font-size:11.0pt;

font-family:Arial;font-weight:bold;font-style:italic’>                                   
</span></font></i></b><b><font

size=2 face=Arial><span style=’font-size:11.0pt;font-family:Arial;font-weight:

bold’>                                        Dr. Gualberto Ruaño<o:p></o:p></span></font></b></p>



<p class=MsoNormal align=center style=’text-align:center’><b><i><font size=6

face=Arial><span style=’font-size:23.0pt;font-family:Arial;font-weight:bold;

font-style:italic’>Physiological Genomics & Personalized Medicine<o:p></o:p></span></font></i></b></p>



<p class=MsoNormal align=center style=’text-align:center’><b><i><font size=2

face=Arial><span style=’font-size:11.0pt;font-family:Arial;font-weight:bold;

font-style:italic’>Presented by:  <u>Dr. Gualberto Ruaño,</u> President &

CEO, Genomas, Inc., <st1:City w:st="on">Hartford</st1:City>, <st1:State w:st="on">CT</st1:State>,

Director of Genetics Research at <st1:place w:st="on"><st1:PlaceName w:st="on">Hartford</st1:PlaceName>

<st1:PlaceType w:st="on">Hospital</st1:PlaceType></st1:place>, and Adjunct

Professor in the medical faculties at <o:p></o:p></span></font></i></b></p>



<p class=MsoNormal align=center style=’text-align:center’><st1:PlaceName w:st="on"><b><i><font

size=2 face=Arial><span style=’font-size:11.0pt;font-family:Arial;font-weight:

bold;font-style:italic’>George</span></font></i></b></st1:PlaceName><b><i><font

size=2 face=Arial><span style=’font-size:11.0pt;font-family:Arial;font-weight:

bold;font-style:italic’> <st1:PlaceName w:st="on">Washington</st1:PlaceName>
<st1:PlaceType

w:st="on">University</st1:PlaceType> and the <st1:place w:st="on"><st1:PlaceType

w:st="on">University</st1:PlaceType> of <st1:PlaceName w:st="on">Puerto
Rico</st1:PlaceName></st1:place>.<o:p></o:p></span></font></i></b></p>



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face=Arial><span style=’font-size:10.0pt;font-family:Arial;font-weight:bold;

font-style:italic’><o:p> </o:p></span></font></i></b></p>



<p class=MsoNormal align=center style=’text-align:center’><b><font size=1

face=Arial><span style=’font-size:8.0pt;font-family:Arial;font-weight:bold’>Dr.

Ruaño, MD, PhD, has a 25-year scientific and medical career that has him

developing systems for DNA-guided medicine based on genomics, nanoscience and

clinical informatics.  At Genomas, he has pioneered physiotypes based on

multi-gene markers and bioclinical algorithms for the prediction of human drug

response and DNA-guided medicine in patient care.  Dr. Ruaño has received many

awards, the most recent being the induction in February 2009 into the American

Institute for Medical and Biological Engineering (AIMBE) <st1:place w:st="on"><st1:PlaceType

w:st="on">College</st1:PlaceType> of <st1:PlaceName w:st="on">Fellows</st1:PlaceName></st1:place>. 

Recipients of this honor are chosen for exceptional leadership and achievements

in medical and biological engineering.<o:p></o:p></span></font></b></p>



<p class=MsoNormal align=center style=’text-align:center’><font size=2

face=Arial><span style=’font-size:11.0pt;font-family:Arial’><o:p> </o:p></span></font></p>



<p class=MsoNormal style=’text-autospace:none’><font size=2 face=Arial><span

style=’font-size:10.5pt;font-family:Arial’>A revolution in our understanding of

human health and disease has been launched by the sequencing of a prototypical

human genome.  To a large degree, this achievement represents the pinnacle of

reductionist scientific thought, as having all genes dissected one could, in

principle, allow reconstitution of the organism.  In contrast, the classical

discipline of physiology has been dealing with systems from its very outset. 

Physiological genomics, henceforth “physiogenomics,” bridges the

gap between the systems approach and the reductionist approach by using human

variability in physiological process, either in health or disease, to drive

their understanding at the genome level.  Physiogenomics utilizes an integrated

approach composed of genotypes and phenotypes and a population approach

deriving signals from functional variability among individuals.  DNA-guided

medicine will cross over the existing specialty silos in organized medicine,

and redefine the layout of the health system.  Therefore, physiogenomic

applications and case studies of DNA-guided medicine for clinical neuroscience,

cardiovascular medicine and diabetes management will be presented in
detail.</span></font><b><font

size=4 face=Arial><span style=’font-size:14.0pt;font-family:Arial;font-weight:

bold’><o:p></o:p></span></font></b></p>



<p class=MsoNormal align=center style=’text-align:center’><b><font size=3

face=Arial><span
style=’font-size:12.0pt;font-family:Arial;font-weight:bold’>Thursday,

June 18, 2009<o:p></o:p></span></font></b></p>



<p class=MsoNormal align=center style=’text-align:center’><b><font size=3

face=Arial><span
style=’font-size:12.0pt;font-family:Arial;font-weight:bold’>Networking

Reception 4:30 – 5:30 PM<o:p></o:p></span></font></b></p>



<p class=MsoNormal align=center style=’text-align:center’><b><font size=3

face=Arial><span
style=’font-size:12.0pt;font-family:Arial;font-weight:bold’>Presentation

5:30 – 7:00 PM<o:p></o:p></span></font></b></p>



<p class=MsoNormal align=center style=’text-align:center’><b><font size=3

face=Arial><span style=’font-size:12.0pt;font-family:Arial;font-weight:bold’>Baystate

Hospital, Chestnut Rooms 1A & 1B, 759 Chestnut Street, Springfield, MA  Free

parking!  <o:p></o:p></span></font></b></p>



<p class=MsoNormal align=center style=’text-align:center’><b><font size=3

face=Arial><span
style=’font-size:12.0pt;font-family:Arial;font-weight:bold’>Directions:

<a

href="http://www.baystatehealth.com/eConsumer/bhs_content_list.jsp?chId=efd682265d33df00VgnVCM1000000f0c19acRCRD&ctName=Page%20Copy&subTypeVal=Directions">http://www.baystatehealth.com/eConsumer/bhs_content_list.jsp?chId=efd682265d33df00VgnVCM1000000f0c19acRCRD&ctName=Page%20Copy&subTypeVal=Directions</a><o:p></o:p></span></font></b></p>



<p class=MsoNormal><font size=3 face=Arial><span style=’font-size:12.0pt;

font-family:Arial’><o:p> </o:p></span></font></p>



<p class=MsoNormal><font size=3 face=Arial><span style=’font-size:12.0pt;

font-family:Arial’><o:p> </o:p></span></font></p>



<p class=MsoNormal align=center style=’text-align:center’><b><font size=3

face=Arial><span style=’font-size:12.0pt;font-family:Arial;font-weight:bold’>NO

CHARGE TO ATTEND, BUT IT WOULD BE APPRECIATED IF YOU RESERVE IN
ADVANCE</span></font></b><font

face=Arial><span style=’font-family:Arial’><o:p></o:p></span></font></p>



<p class=MsoNormal style=’margin-left:1.0in;text-indent:.5in’><font size=3

face=Arial><span style=’font-size:12.0pt;font-family:Arial’>RSVP to:  Terri

Wilson – 860-547-1995 or toll free:  877-723-2266<o:p></o:p></span></font></p>



<p class=MsoNormal style=’margin-left:2.0in;text-indent:.5in’><font size=3

face=Arial><span style=’font-size:12.0pt;font-family:Arial’>Email:  <a

href="mailto:theresa.wilson@beaconalliance.org">theresa.wilson@beaconalliance.org</a>                                
<o:p></o:p></span></font></p>



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