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<div id=cover-sheet>Please join us for the third seminar in the Pfizer Series
organized by BEACON on June 18 discussing DNA-guided medicine. This event is
co-presented by the Pioneer Valley Life Sciences Institute in Springfield, MA.
Full details are attached. We hope you can attend. Please share, post or
blast this information to your colleagues! It is open to the public free of
charge. RSVP requested.
<hr>
</div>
<div class=Section1>
<p class=MsoNormal align=center style=’text-align:center’><img
width=168 height=104 id="_x0000_i1025" src="cid:image001.jpg@01C9D95B.1F81C760"></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style=’font-size:
12.0pt’><o:p> </o:p></span></font></p>
<div style=’mso-element:para-border-div;border:solid #0099CC 2.25pt;padding:
0in 0in 1.0pt 4.0pt;margin-left:1.5in;margin-right:1.5in’>
<p class=MsoNormal align=center style=’text-align:center;border:none;
padding:0in;padding-bottom:0in;border-bottom:2.25pt solid #0099CC’><b><i><font
size=5 color="#003399" face="Times New Roman"><span style=’font-size:16.0pt;
color:#003399;font-weight:bold;font-style:italic’>Organized and presented by: <o:p></o:p></span></font></i></b></p>
<p class=MsoNormal align=center style=’text-align:center;border:none;
padding:0in;padding-top:0in’><b><i><font size=5 color="#003399"
face="Times New Roman"><span style=’font-size:16.0pt;color:#003399;font-weight:
bold;font-style:italic’><img width=99 height=53 id="_x0000_i1026"
src="cid:image002.jpg@01C9D95B.1F81C760"> </span></font></i></b><img
width=287 height=58 id="_x0000_i1027" src="cid:image003.gif@01C9D95B.1F81C760"><b><i><font
size=5 color="#003399"><span style=’font-size:16.0pt;color:#003399;font-weight:
bold;font-style:italic’><o:p></o:p></span></font></i></b></p>
</div>
<p class=MsoNormal align=center style=’text-align:center’><font size=3
face="Times New Roman"><span style=’font-size:12.0pt’><o:p> </o:p></span></font></p>
<p class=MsoNormal style=’margin-left:1.5in’><font size=3 face="Times New
Roman"><span
style=’font-size:12.0pt’> <img
width=84 height=126 id="_x0000_i1028" src="cid:image004.jpg@01C9D95B.1F81C760"></span></font></p>
<p class=MsoNormal><b><i><font size=2 face=Arial><span style=’font-size:11.0pt;
font-family:Arial;font-weight:bold;font-style:italic’>
</span></font></i></b><b><font
size=2 face=Arial><span style=’font-size:11.0pt;font-family:Arial;font-weight:
bold’> Dr. Gualberto Ruaño<o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style=’text-align:center’><b><i><font size=6
face=Arial><span style=’font-size:23.0pt;font-family:Arial;font-weight:bold;
font-style:italic’>Physiological Genomics & Personalized Medicine<o:p></o:p></span></font></i></b></p>
<p class=MsoNormal align=center style=’text-align:center’><b><i><font size=2
face=Arial><span style=’font-size:11.0pt;font-family:Arial;font-weight:bold;
font-style:italic’>Presented by: <u>Dr. Gualberto Ruaño,</u> President &
CEO, Genomas, Inc., <st1:City w:st="on">Hartford</st1:City>, <st1:State w:st="on">CT</st1:State>,
Director of Genetics Research at <st1:place w:st="on"><st1:PlaceName w:st="on">Hartford</st1:PlaceName>
<st1:PlaceType w:st="on">Hospital</st1:PlaceType></st1:place>, and Adjunct
Professor in the medical faculties at <o:p></o:p></span></font></i></b></p>
<p class=MsoNormal align=center style=’text-align:center’><st1:PlaceName w:st="on"><b><i><font
size=2 face=Arial><span style=’font-size:11.0pt;font-family:Arial;font-weight:
bold;font-style:italic’>George</span></font></i></b></st1:PlaceName><b><i><font
size=2 face=Arial><span style=’font-size:11.0pt;font-family:Arial;font-weight:
bold;font-style:italic’> <st1:PlaceName w:st="on">Washington</st1:PlaceName>
<st1:PlaceType
w:st="on">University</st1:PlaceType> and the <st1:place w:st="on"><st1:PlaceType
w:st="on">University</st1:PlaceType> of <st1:PlaceName w:st="on">Puerto
Rico</st1:PlaceName></st1:place>.<o:p></o:p></span></font></i></b></p>
<p class=MsoNormal align=center style=’text-align:center’><b><i><font size=2
face=Arial><span style=’font-size:10.0pt;font-family:Arial;font-weight:bold;
font-style:italic’><o:p> </o:p></span></font></i></b></p>
<p class=MsoNormal align=center style=’text-align:center’><b><font size=1
face=Arial><span style=’font-size:8.0pt;font-family:Arial;font-weight:bold’>Dr.
Ruaño, MD, PhD, has a 25-year scientific and medical career that has him
developing systems for DNA-guided medicine based on genomics, nanoscience and
clinical informatics. At Genomas, he has pioneered physiotypes based on
multi-gene markers and bioclinical algorithms for the prediction of human drug
response and DNA-guided medicine in patient care. Dr. Ruaño has received many
awards, the most recent being the induction in February 2009 into the American
Institute for Medical and Biological Engineering (AIMBE) <st1:place w:st="on"><st1:PlaceType
w:st="on">College</st1:PlaceType> of <st1:PlaceName w:st="on">Fellows</st1:PlaceName></st1:place>.
Recipients of this honor are chosen for exceptional leadership and achievements
in medical and biological engineering.<o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style=’text-align:center’><font size=2
face=Arial><span style=’font-size:11.0pt;font-family:Arial’><o:p> </o:p></span></font></p>
<p class=MsoNormal style=’text-autospace:none’><font size=2 face=Arial><span
style=’font-size:10.5pt;font-family:Arial’>A revolution in our understanding of
human health and disease has been launched by the sequencing of a prototypical
human genome. To a large degree, this achievement represents the pinnacle of
reductionist scientific thought, as having all genes dissected one could, in
principle, allow reconstitution of the organism. In contrast, the classical
discipline of physiology has been dealing with systems from its very outset.
Physiological genomics, henceforth “physiogenomics,” bridges the
gap between the systems approach and the reductionist approach by using human
variability in physiological process, either in health or disease, to drive
their understanding at the genome level. Physiogenomics utilizes an integrated
approach composed of genotypes and phenotypes and a population approach
deriving signals from functional variability among individuals. DNA-guided
medicine will cross over the existing specialty silos in organized medicine,
and redefine the layout of the health system. Therefore, physiogenomic
applications and case studies of DNA-guided medicine for clinical neuroscience,
cardiovascular medicine and diabetes management will be presented in
detail.</span></font><b><font
size=4 face=Arial><span style=’font-size:14.0pt;font-family:Arial;font-weight:
bold’><o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style=’text-align:center’><b><font size=3
face=Arial><span
style=’font-size:12.0pt;font-family:Arial;font-weight:bold’>Thursday,
June 18, 2009<o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style=’text-align:center’><b><font size=3
face=Arial><span
style=’font-size:12.0pt;font-family:Arial;font-weight:bold’>Networking
Reception 4:30 – 5:30 PM<o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style=’text-align:center’><b><font size=3
face=Arial><span
style=’font-size:12.0pt;font-family:Arial;font-weight:bold’>Presentation
5:30 – 7:00 PM<o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style=’text-align:center’><b><font size=3
face=Arial><span style=’font-size:12.0pt;font-family:Arial;font-weight:bold’>Baystate
Hospital, Chestnut Rooms 1A & 1B, 759 Chestnut Street, Springfield, MA Free
parking! <o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style=’text-align:center’><b><font size=3
face=Arial><span
style=’font-size:12.0pt;font-family:Arial;font-weight:bold’>Directions:
<a
href="http://www.baystatehealth.com/eConsumer/bhs_content_list.jsp?chId=efd682265d33df00VgnVCM1000000f0c19acRCRD&ctName=Page%20Copy&subTypeVal=Directions">http://www.baystatehealth.com/eConsumer/bhs_content_list.jsp?chId=efd682265d33df00VgnVCM1000000f0c19acRCRD&ctName=Page%20Copy&subTypeVal=Directions</a><o:p></o:p></span></font></b></p>
<p class=MsoNormal><font size=3 face=Arial><span style=’font-size:12.0pt;
font-family:Arial’><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face=Arial><span style=’font-size:12.0pt;
font-family:Arial’><o:p> </o:p></span></font></p>
<p class=MsoNormal align=center style=’text-align:center’><b><font size=3
face=Arial><span style=’font-size:12.0pt;font-family:Arial;font-weight:bold’>NO
CHARGE TO ATTEND, BUT IT WOULD BE APPRECIATED IF YOU RESERVE IN
ADVANCE</span></font></b><font
face=Arial><span style=’font-family:Arial’><o:p></o:p></span></font></p>
<p class=MsoNormal style=’margin-left:1.0in;text-indent:.5in’><font size=3
face=Arial><span style=’font-size:12.0pt;font-family:Arial’>RSVP to: Terri
Wilson – 860-547-1995 or toll free: 877-723-2266<o:p></o:p></span></font></p>
<p class=MsoNormal style=’margin-left:2.0in;text-indent:.5in’><font size=3
face=Arial><span style=’font-size:12.0pt;font-family:Arial’>Email: <a
href="mailto:theresa.wilson@beaconalliance.org">theresa.wilson@beaconalliance.org</a>
<o:p></o:p></span></font></p>
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