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Interest Group homepage at https://www.lab-robotics.org Presentation: Validation of
Engineered Cell-Based Screens for G Protein-Coupled Receptors
E. William Radany, Ph.D.
Business Manager
Stratagene
G protein-coupled receptors and receptor tyrosine kinases are important targets for drug discovery. High throughput screening (HTS) assays based on ligand binding to these targets may yield biased results depending on the cellular environment in which the cloned receptor resides. The use of engineered cell lines of defined signalling properties with specific receptors provides new tools for HTS assays and the the study of orphan receptors. This presentation will focus on the development of discovery platforms based on reporter gene technology utilizing cells with specific signalling pathways.
Table of ContentsValidation of Engineered Cell-Based Screens for G Protein-Coupled Receptors Development of Engineered Cells for G Protein-Coupled Receptor Screening |
Author: E. William Radany |
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Interest Group homepage at https://www.lab-robotics.org