Why a manual process must change to be automated
Format of automated pipettors may not allow the use of your current labware
Liquid transfer characteristics of solvents/reagents may require changes in concentration
Sample sealing methods are highly automation unfriendly, some more than others (capping tubes especially)
Limited automated centrifuge options, especially for plates!
On-deck refrigeration and incubation are slow and costly
Favored analysis equipment may not be integratable