The a II, a/b III, and a/b V peptides inhibit tamoxifen partial agonist activity

Collagenase promoter

Responsive to tamoxifen through AF-1 region

0

20

40

60

80

100

120

Estradiol

Tamoxifen

% Activation

control

?/? I

? II

?/? III

?/? V

Norris et al. (1999) Science 285, 744-746

Peptide

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