Peptide Validation: The peptides disrupt ER/ERE mediated transcription
0
20
40
60
80
100
120
140
% Activation
Tamoxifen
Control
??? I
??II
??? III
??? V
0
20
40
60
80
100
120
% Activation
Estradiol
Control
??? I
??II
??? III
??? V
3X C 3
Luc
Complement 3 promoter
Responsive to Estradiol and Tamoxifen
Peptide
Gal4
Plasmid 1
Plasmid 2
Norris et al. (1999) Science 285, 744-746
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