Example: The Estrogen Receptor

• Pharmacology:

  • Breast cell proliferation
  • Uterine cell proliferation
  • Cognitive function
  • Bone-density regulation
  • Cardiovascular protection

• Biology:

  • Localized in nucleus
  • Unliganded protein binds to HSP complex
  • Ligand binding induces conformational changes, release of HSP, dimerization, and DNA binding
  • Co-activator binding induces transcription

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