TE671 Cells, Schild Analysis (on-rate):Arachidonic Acid as a Non-competitive Antagonist of M3 Receptor

-6

-5

-4

-3

-2

0

1

2

3

Acetylcholine (Log M)

-7

-6

-5

-4

-3

-2

0

1

2

3

Carbachol (Log M)

Arachidonic Acid, mM:

1 - 0

2 - 0.03

3 - 0.10

4 - 0.30

5 - 1.00

6 - 3.00

Max Response

Max Response

EC50

EC50

1

2

3

4, 5

6

1

2

3, 4

5

6

Arachidonic Acid, mM:

1 - 0

2 - 0.03

3 - 0.10

4 - 0.30

5 - 1.00

6 - 3.00

D R 340/380

D R 340/380

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