Liquid-Liquid Extraction Protocols

Issues

• Solubility of Organic layer in water

• Solvent volatility

• Workup of DCM reactions

• Workup of DMF Reactions

• Precipitates formed in

Quench

Solution

Pre-saturate water with Organic Solvent

Prefer water as bottom layer (waste); organic = MTBE, isopropyl acetate

Prefer MTBE (2:1), density = 0.74

2 washes, remove: 99.5% DMF

Decant top organic layer

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