PPT Slide

• Ti(OiPr)4 mediated reductive amination:

  • Selective mono-alkylation of primary amines
  • Broad Scope with reactive aldehydes, enolizable and hindered carbonyl compounds

• Amines purified by:

  • Aqueous quench, followed by filtration of TiO2
  • Amine as limiting reagent allows Catch and release with MP-TsOH

Robust protocol amenable to automation

Reductive Amination:

Preparation of Secondary Amines

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