PPT Slide

• Thioureas and Bromoketones allowed to react at the reflux temperature (12 h)

• Products precipitate on formation (R1= H) or cooling

• Filtration in Cassette affords product
  • No plugging of Frits

• Purified by Cold acetone Wash

• Dissolve aminothiazole hydrobomide in DMF

• Free-base with bound amine (PS-DIEA)

2-Aminothiazoles: Hantzch Synthesis

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