PPT Slide
- n-BuLi lithiation (0.9 equiv.) + Aldehyde quench (0.8 equiv.)
- Lithium alkoxides collected over PS-DIEA-HCl to quench
- Resin bound amine hydrochloride, ~ 50% water
- Removes lithium chloride
- Filtration, concentration affords product
Thiophene Metallation and Quench