Parallel Purification Methods:

• Scavenging

  • Chemically-driven separation using functional polymers
  • Added after reaction is complete, removed by filtration

• SPE

  • Solute absorbs on solid phase Media in Cartridge
  • Purified Product isolated by:
    • Method A:
      • Elute product
      • Byproducts remain absorbed on Media
    • Method B:
      • Elute byproducts
      • Release Product with strong solvent
    • Media:
      • Silica gel (Polar), C-18 (reverse phase)
      • -SO3H modified silica gel (ionic)

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