Goals of Lead Optimization
More pressure to produce compounds faster
Maximize speed and efficiency:
- Make what you eed?to make, not what is easy
- Get more information to target in on a candidate
- Automate reactions which are important to Med Chem
- Automate purification and workup
- Use automation that works
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Make libraries that produce quality compounds:
- Focused
- fill in holes in diversity space
- targeted around a structure
- matched to a therapeutic area
- High Quality: purity and structural diversity
- Consistent: conditions of synthesis are uniform