Historical Perspective

1995--CombiChem Groups formed

• Lead Discovery

• Large Libraries--5,000 to 10,000 per month

• Solid Phase

• Limited Chemistries

  • low quality

• Heavy Investment in Automation

• Limited Success

  • Worked for Lead Discovery
  • Not the complete answer

Now: Focus on Lead Optimization process

• Accelerate the process

• Focused Libraries

• Solution Phase

• Complex Chemistry

• Maintain Quality with Automation

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