Table of Contents
Trident Library Synthesizer For Automation of Multistep Solution Phase Synthesis
Agenda
Historical Perspective
Goals of Lead Optimization
Applications for Automated Synthesis are Changing
Range of Chemistries
High Throughput Lead Optimization Workflow
Solution Phase Synthesis:
Critical Parameters
Solution Phase Library Synthesis:
Purification Methods
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Synthesize Without Compromise
The Heart of the System
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Reagent & Solvent Delivery
Validation of System Using
Precise Air-Sensitive Deliveries
Validation of System: Results
High Throughput Lead Optimization Workflow
Trident Modules:
Scalable Technology
Chemistry Development
and Rehearsal
Purification
Where Trident Fits into the Process
Chemistry Validation
Parallel Purification Methods:
Working with "Hot" Reagents
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Working with Precipitates
2-Aminothiazoles
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Split Synthesis on Trident
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Split Synthesis
Automating Tedious Purification Steps
Trident SPS:
Liquid-Liquid Extraction
Liquid-Liquid Extraction Protocols
Multistep Synthesis
Benzimidazoles
PPT Slide
Focused Library Synthesis of 48 Benzimidazoles on Automated Platform
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Trident Synthesizer:
Air-sensitive reagents
Automated Approach
Semi-Automated Approach
Trident Technology provides a Flexible Synthesis platform
Acknowledgement
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