The Laboratory Robotics Interest Group
Mid Atlantic Chapter
September 2008 Meeting
New High Content In Vitro/ Vivo Technologies
Date: Wednesday, September 24, 2008
Place:
Crowne Plaza Somerset-Bridgewater ,
110 Davidson Avenue, Somerset NJ 08873
Phone:
1-877-270-1393
Itinerary: Social Period: 5:30 to 6:00 pm
Presentations: 6:00 to 8:00 PM
Registration: We have an on-line registration service at <https://www.lab-robotics.org/member/meetings.asp?rid=1>.
Food and refreshments will be available FREE OF CHARGE
during the Social Period.
There
is always a Job posting board at the social. Please encourage your
recruitors to give you material to post and distribute.
Openings may be also posted at
https://www.lab-robotics.org/forum/default.asp?CAT_ID=2
There is no fee to attend the meeting.
Presentation: Cellix
Microfluidic Biochips Mimicking Human Capillaries
Specificity, accuracy and
in vivo relevance are key drivers in the decision making process for
progression of drug candidates through the lead optimisation and drug
development into animal models. Tools that deliver pertinent data in
vitro facilitate better decisions and the selection of the best drug
candidates. Understanding how cells adhere and move is a rapidly growing area of
research, yet an assay to successfully replicate in vivo conditions
has, until now, proved elusive. The Cellix VenaFlux Platform is the first
automated system capable of mimicking cellular behaviour in human capillaries.
Validated, dynamic, live cell, flow assays deliver quantitative analysis of drug
candidates in cell rolling, arrest, adhesion and migration in the presence of
potential drugs in oncology, bacteriology, respiratory, cardiovascular,
immunology, autoimmune, and infectious diseases. Current research using the
VenaFlux platform in the area of oncology (1) and cardiovascular biology (2) are
briefly outlined.
(1) Melanoma is the most aggressive
form of skin cancer, which invades into deeper layers of the skin and has a
propensity to metastasise early. There are several steps in this metastasis
process. In this study, we modelled survival in circulation and adhesion to
endothelial cell-derived proteins to determine if these steps in extravasation
differed in an isogenic melanoma cell line model of progression.
(2) Platelet adhesion is an essential function in response to
vascular injury, initiating thrombus formation that arrests hemorrhage and
permits wound healing. Data obtained using the VenaFlux platform identified that
the threshold limit of 60 dyne/cm2 is required for thrombus formation
on vwf, conditions that occur in microcirculation. The platform was used to
screen anti-platelet drugs to show their effectiveness in preventing platelet
adhesion.
The VenaFlux platform allows
researchers to perform in-vitro assays mimicking in-vivo
conditions of the blood vessel, providing powerful physiologically relevant data
before compounds reach clinical trials.
Presentation: Tumor
Imaging System
Dr. Cem Girit, Biopticon
Tumor size or volume is often the primary endpoint
in preclinical cancer efficacy studies. Efficient and accurate measurement
of such tumors
is crucial to the rapid evaluation of novel drug candidates. Currently
available techniques for acquiring high throughput data on tumor volume are
time-consuming and they are prone to various inaccuracies and errors. The
laser scanning technology described in this talk provides a convenient, high
throughput system for the measurement of tumors that reduces inter-operator
variability and bias while providing automated data collection, processing and
analysis.
Directions
From Newark - EWR 28.0 mi
Take NJ Turnpike South to Exit 10- I-287 North to Exit 10
(Easton Ave) to first light, go left on Davidson Ave. Hotel
immediately on left.
From New York/La Guardia - LGA 50.1 mi SW
After exiting Airport on LA Guardia Road, merge onto Grand
Central Pkwy W. Take Exit 4 for Bkln-Qns Expy to Staten
Island, then merge to Brooklyn-Queens Expy E. Continue and
exit to I-278 W, take exit 5 to merge to Pearl Harbor Expy (Rt
440) South. Take Rt 440 S to Outerbridge Crossing/Perth
Amboy/Exit1. Continue on I-287 N. Take Exit 10 (East
Ave/CR-527), keep right to CR 527 N/Easton Ave. Lefton
Easton, then left again on Davidson Ave.
On-line directions may be found at:
Crowne Plaza Somerset
Menu
Deli Wraps
Mixed Field Greens with Cucumbers, Tomatoes, Black
Olives, and Sliced Red Onions with a choice of dressings
Cucumber Salad, Red Skin Potato Salad, and Freshly Made
Pasta Salad
Veggie Wrap - Grilled Portabella Mushrooms, Green and
Yellow Zucchini Squash, Diced Peppers and Onions in Balsamic Vinegar Marinade
Chef Specialty Wrap - Shredded Sirloin of Beef,
Cheddar Cheese, Caramelized Onions, with a Creamed Horseradish Sauce
Reuben Wrap - Freshly Baked Corned Beef, Swiss
cheese, Sauerkraut, with a Thousand Island Dressing
The Jersey Pizza Kitchen
Garlic Bread, Breadsticks, Flatbreads and Assorted Rolls
Chicken Caesar Salad
Italian Sub Sandwiches
Assorted Pizza Selections
Chef Hot Pasta Creation
Chef Specialty Pastries and Cookies
(Cheesecake, Ice Cream and 丱lairs, Chocolate Mousse, etc)
Assorted Diet and Regular Soft Drinks
Poland Spring Water
Freshly
Brewed Columbian Coffee Decaffeinated Coffee and Herbal Teas
Visit The Laboratory Robotics
Interest Group homepage at https://www.lab-robotics.org
