The Laboratory Robotics Interest Group
April 2001 Meeting
Combinatorial Chemistry / High Throughput
Screening
Date: Thursday, April 26,
2001
Place: Forsgate Country Club, Forsgate Drive,
Jamesburg, NJ 08831
Phone: (732)521-0070
Itinerary: Social Period - 4:00 to 6:00 PM
Presentations - 6:00 to 8:00 PM
Member Pre-Registration: REQUESTED, not required. Pre-registering will allow
us to more accurately gauge seating requirements and refreshment
needs. Indicate names of attendees and company affiliation. Pre-register
by email with <mailto:[email protected]>. In order to speed sign-in at the meeting, please bring
a business card to drop into the registration box. There will be a
business card drawing for one of our beautiful LRIG rosewood pens and any vendor
supplied prizes.
Agenda:
This meeting is focused on Combinatorial Chemistry and High Throughput Screening
technologies. Food and refreshments will be available FREE OF CHARGE
during the Social Period.
The menu includes:
International and Domestic Cheeses, French Breads
Crackers and Fresh Fruit Garnish
Garden Display of Crudite Vegetables
Salsa & Chips
Miniature Beef Wellingtons
Smoked Salmon and Cream Cheese Canapes
Jumbo Mushroom Caps with Crab and Artichoke
Vegetable Egg Rolls, Plum Sauce
Sesame Chicken, Peanut Dipping Sauce
Ham, Cheese and Asparagus Rolls
Cheese and Spinach Phyllo Triangles
Mini Hot Dogs
Spinach and Cheese Tortellini, Roast Pepper Sauce, Radiatore Pomodoro
Garlic Bread and Parmesan Cheese
Thank you, Aurora Biosciences
Corporation, for contributing towards the food and refreshments!
There are hotels nearby for attendees who wish to stay
overnight.
There will be a Job posting board at the social. Please encourage your recruiters to
give you material to post and distribute. Openings may also be posted at https://www.lab-robotics.org/careers.htm
Members interested in presenting a scientific poster are encouraged to do so. Please
contact us to arrange for poster space.
There is no fee to attend the meeting.
Presentation: High Throughput ADME Screening
Brian Bockhorn, D. Galinis, Ph.D., Anna Mollin, Joanne Rivera and Charles
Stewart, Ph.D.
Coelacanth Corporation, East Windsor, NJ
High throughput synthesis and screening efforts can produce thousands of
potential lead structures creating a bottleneck in the optimization process. The
prioritization of these leads for follow-up often becomes an issue. Compounds
may be ranked in terms of potency but often the most effective compound does not
have the most favorable ADME/PK properties. At Coelacanth we have developed a
strategy for characterizing the pharmaceutical properties of our library
compounds in a high throughput mode. The screening methods and the valuable
information that is obtained using this approach will be discussed.
Presentation: A Comparison of
the AlphaScreenTM System with the LANCETM and DELFIATM
System For High Throughput Screening
J. Fraser Glickman, Ph.D., Yang He and Sean Wu, Ph.D.
Novartis Institute for Biomedical Research, Summit, NJ 07901
An assay for nuclear receptor ligands was converted from LANCETM and
DELPHIATM formats to an AlphaScreenTM format. The AlphaScreenTM assay showed a
remarkable increase in signal to background ratio, and sensitivity to analyte.
The dramatic increase in sensitivity resulted in reduced reagent use, and helped
to enable the miniaturization process. The AlphaQuestTM optical detection
instrument was able to read plates four-fold faster than a more conventional
time-gated fluorescence plate reader, via a multi-PMT system, thus reducing time
of the screening process.
Presentation: Micro-volume liquid
dispensing. Analysis and examples.
Ilya Feygin, Manager Research Engineering
Pharmacopeia, Inc, Princeton, NJ
Precise dispensing of micro volumes of reagents in liquid form becomes
more and more important with continuing miniaturization of the High Throughput
and High Content Research process. Applicable to all platforms, from medium and
high density plates to "micro-chips", fast and repeatable liquid
dispensing can often become the key to a successful experiment.
Various methods of existing dispensing technologies will be analyzed and
Pharmacopiea's experience in implementing high speed dispensing will be
presented.
Presentation:
Experience
with integration and bringing Aurora UHTSS system on-line at Merck
Oleg Kornienko
Merck
I will discuss the role of HTS/UHTSS in drug discovery process and where
Aurora's UHTSS fits in it. Basic principles of Aurora's technologies and
technical limitations will be overviewed. Performance and reliability as well as
basic timelines of operation will also be presented. The talk will be concluded
by a video demonstration of integrated system in action and a brief discussion
of future enhancements and development.
DON'T FORGET TO PRE-REGISTER TO INSURE THAT THERE IS ENOUGH FOOD AND SEATS.
Just send an email to [email protected]
Directions:
From the North or South: Take the New Jersey Turnpike
to Exit 8A - Exit the left ramp for Jamesburg (Route 32 East) - Continue straight for 1
1/4 miles through traffic light - Forsgate Country Club is on your left - Use the
Clubhouse Entrance (second left).
From Princeton: Route 1 to Scudders Mill Road East -
Continue on Scudders Mill Road and make a left at the 5th traffic light onto Dey Road -
Continue on Dey Road to the end - Make a left - At 2nd traffic light (Route
32) make a right - Continue straight for 1 1/4 miles through traffic light - Forsgate
Country Club is on your left - Use the Clubhouse entrance (second left).
For an interactive map:
Visit The Laboratory Robotics
Interest Group homepage at https://www.lab-robotics.org
