"IonWorksTMHT - A New High-Throughput Electrophysiology Measurement Platform"

Jennings Worley, Amphora Discovery Corporation

In order to eliminate the throughput restrictions of classical patch clamp electrophysiology, Essen Instruments has developed a plate-based ion channel measurement platform. The system is capable of measuring whole-cell electrophysiological recordings in a manner which allows for thousands individual cells to be tested in an 8-hour day. Data demonstrating typical throughput, measurement fidelity and comparative pharmacology will be presented for Type III Na channels, the voltage-gated potassium channel Kv1.5 and hERG. The commercialized instrument is called IonWorks^TM HT and will be sold and supported by Molecular Devices Corporation.