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1
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- Diane Johnson, Craig Hines, Lenny Vodonos
- Laboratory Robotics Interest Group
- February 2008
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2
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- Scientific Business Objectives
- Layout of Kings Heights
- Global Operations Support Model
- Infrastructure Systems
- Overview Liquid Store, DNA & BioFluids Centers of Emphasis
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3
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- Improve collaborative efforts between KHTC Science Lines and Global
Operations. Partner with Global Operations, implement a consolidated
service delivery model that will support all scientific goals and
objectives by streamlining all services in the most efficient and cost
effective manner.
- Empower Global Operations, drive the success of the customers by
delivering cost-effective services and solutions that enhance
productivity.
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4
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- KHTC Global Operations will provide a wide variety of services:
- Management of service contracts and contractual relationship with
service providers
- Scheduling and coordination of preventative maintenance/demand repair
work
- Handling service related documentation
- Facility Center asset management
- 24/7 monitoring and equipment emergency response
- Production process consumable supply
- Tracking and lab support technical services.
- Science Lines and Global Operations will collaboratively develop and
implement Lab Instrumentation Service Contracts for robotic equipment
and instrumentation services with proprietary equipment vendors. The
contracts are based on customer business needs, Global Operations
standards, performance matrices, and negotiated prices.
- Improved equipment reliability
- 15% contract price reduction
- Enable the lab personnel to focus on their core business
- Increase productivity (less time needed to manage equipment-related
issues)
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5
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- KHTC site, formerly known as Caldor Shopping Plaza, was purchased by
Pfizer in 1998. It is a 15-acre site located off Route I-95
approximately 10 minutes from the Groton Global R&D Campus.
- The KHTC facility was officially opened in September 2001 and quickly
rose to become one of the most technologically advanced facilities
within Pfizer portfolio.
- Since its opening, the site has been in a state of continuous
transformation:
- Pharmaceutical Science Stability Study Administration
- Liquid Compound Center of Emphasis: Compound Plate Replication, REMP
Storage and Distribution @ -20˚C
- -20˚C/-80˚C Freezer Archive
- DNA & BioFluids Center of Emphasis: DNA Extraction, DNA
Normalization, DNA & BioFluid Plate Replication, REMP Storage and
Distribution @ -20˚C & -80˚C
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6
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7
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8
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- Enable Scientific Lines to focus on core business goals and objectives
by anticipating requirements and fully meeting expectations
- Develop cost effective and agile operational model
- Provide reliable and flexible infrastructure capable of supporting
cutting edge scientific objectives
- Provide safe & productive work environment
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9
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- Fully Integrated and Outsourced Facilities Operations Model that meets
all Customer Needs at a Competitive Price
- Single Point-of-Contact & Accountability for Customer Groups
- Alignment with Scientific Culture & Business Objectives
- Effective Contracts and Service Level Agreements
- Operational Efficiencies, Data Collection and Validation
- Emergency Response and Contingency Plans
- 24/7 Monitoring of Critical Equipment and Systems
- Continuous Improvements and Innovation
- Global Operations collaboration efforts with Scientific Lines in
planning site programs and delivering services
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10
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11
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12
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- Close Transition ATS and 225 KVA UPS switches power with
- no momentary interruptions to vital building systems & robotics
- All Cooling and Heating Systems
are N+1 configuration. Dual Fuel Boilers. 388 alarm points are monitored
24/7 by Control Room
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13
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14
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- Cooling Sample Storage Systems are 100% redundant
- Intermediate -20˚C Carousel
- Storage Space (8000 cubic feet)
- Long Term -80˚C Sample Storage
- Cascade Systems (1400 cubic feet)
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15
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16
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- Goals:
- Maintain consistent Compound Production Lab relative humidity and
temperature 12 months a year.
- Not an easy thing to accomplish in New England!
- Challenges:
- Limited building systems capacity
- Remove moisture from outside air
- Uninterruptible sample production & stability labs
- Lack of available building space
- Restricted utility and emergency backup power
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17
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18
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- Requirements:
- Standardization of global business rules
- High degree of stewardship
- Improve quality of product and data
- Improve delivery time
- Central Repository for all liquid samples
- Outcome:
- Centralized processing
- Single point of contact for shipping & receiving
- Global availability for all liquid samples
- Maximize capital equipment utilization
- Optimal personnel deployment
- Reliable distribution
- Highest Quality Sample Integrity
- Sample Tracking / Audit trail
- Experienced team to manage a large -20˚c/-80˚c storage
facility
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19
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- Minimizes Freeze Thaw Cycles
- Global ordering software
- REMP -20° store Fully
automated storage and retrieval
- Stores about 60,000,000 Single Use 384 well Tubes
- Process Turn Around Time < 24 hours
- Storage of liquid compounds & libraries
- 2 ul (retest) or 10 ul (IC50) @ 4 & 30 mM
- Delivery - 96 or 384 well format
- Control wells or not
- Empty tubes in control wells or not
- Fill by row or fill by column
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20
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21
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- REMP combination -20°/-80°C store
- Storage of biological samples
- -20°C – DNA
- -80°C – blood, serum, plasma,
urine, etc.
- Single store – reduced ECU costs
- Challenges
- Temperature flux during tube picking
- Condensation
- Access rates
- Migration/transition from legacy systems to REMP Store
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22
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23
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24
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25
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- Project Management - Understanding, tolerance, perseverance, clarity of
purpose and humor essential with multiple vendors interacting
- User requirements for IT demanding and frustrating
- Align business practices with systems feasibility and practicality
- Prototype freezers require adaptability and flexibility in schedules
- New England humidity/condensation is highly variable
- Consumables -20°C/-80°C
- Leverage common global systems
- REMP API
- Pfizer Compound Liquid Store Application, Oracle data base, API, VPN
Access, Servers and Firewalls
- Migration/transition from legacy systems to REMP Store
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26
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27
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- DNA & BioFluids CoE
- Diane Johnson
- Jason Harraden
- Kathy Landry
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Notes
