1
2	RUCDR Supporting Human Gene Discovery
3	RUCDR Mission Statement Rutgers University Cell and DNA Repository (RUCDR) plays a key role in research aimed at understanding the genetic causes of common, complex diseases. RUCDR activities will enable gene discovery leading to diagnoses, treatments and, eventually, cures. The RUCDR is a separate business entity within the Department of Genetics, and a division of the Human Genetics Institute at Rutgers University.
4	RUCDR History In late 1998 the Cell Repository opened it’s doors It consisted of a handful of employees, cryotanks and freezers moved from IUSOM to Rutgers In early 1999, work had begun on identity, growth and future expansion In 2005, The RUCDR partnered with the Bionomics Research and Technology Center (BRTC), a division of EOSHI-RWJMS-UMDNJ.
5
6	RUCDR Background Info Largest university based repository in the world Currently, > 20K sq.ft. with 14 laboratories Exceeds ISBER best practices guidelines Biosample processing Cryogenic storage Custom database
7
8	“Let’s Talk Numbers…” Sample receipts Sites PI’s Distributions Contracts/grants Annual budget Employees Storage capacity
9	Repository Growth
10	What is a Biorepository? A biorepository is more than just a cell bank or a tissue library…it is an active resource Four primary functions of a Biorepository Sample acquisition Processing Storage Distribution
11
12
13
14
15	“A Need for Speed” via Automation
16	When should you Automate? Choke points or rate limiting activities Cost-benefit analysis Quality Technology Timing
17	Sample Processing Flow
18	Information Management The minimum necessary requirements: Track Audit trail Manage / Integrate Reports Security and data backup In-house database or subcontract Database Repository
19	RUCDR LIMS Database Schema
20
21
22
23
24
25
26
27
28	Compliance HIPAA IRB Consents IATA Other Institutional State Government
29
30	Preparing for the Future In other words…“get there before the future arrives” How do I find out where “there” is? Forecasting / Trends Science Business Funding opportunities Government Private Facilities / Equipment / Space Disaster recovery Do your homework to minimize the risk…
31	RUCDR and the Future Biosample storage Biosample processing New technologies Additional services New LIMS system
32	Sponsoring Agencies National Institute on Alcohol and Alcohol Abuse (NIAAA) Cell lines and DNA samples have been banked since 1990 from families with a high incidence of alcoholism
33	Sponsoring Agencies National Institute on Drug Abuse (NIDA) Opiates Cocaine Nicotine
34	Sponsoring Agencies National Institute of Mental Health (NIMH) Schizophrenia Bipolar Disorder Alzheimer’s Disease Autism Obsessive-Compulsive Disorder (OCD) Depression ADHD
35	Sponsoring Agencies National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Type I Diabetes Inflammatory Bowel Disease Chronic and Acute Kidney Diseases Chronic and Acute Liver Diseases
36	2006: Genetic Association Information Network (GAIN) Announces Genotyping Awards for Six Common Diseases “GAIN is a critical first step in identifying the genetic factors that influence disease susceptibility and health, and it is essential to choose studies that offer the best possible potential to find these factors in common diseases," said Francis S. Collins, M.D., Ph.D. Four of the six studies selected for this initiative are housed at the RUCDR As DNA samples from each study are genotyped, the results will be made broadly available to the research community in keeping with the principles pioneered by the Human Genome Project.
37